منابع مشابه
Protein kinase Cδ in tumorigenesis of human malignant fibrous histiocytoma.
Protein kinase Cδ (PKCδ), an isoform of PKC, has been shown to act as a critical mediator of tumor progression and apoptosis; however, its role in musculoskeletal tumors is still unknown. In the current study, we examined the expression of PKCδ in human musculoskeletal tumor tissue samples, and investigated the effects of siRNA downregulation of PKCδ on human malignant fibrous histiocytoma (MFH...
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Protein kinase C (PKC) is one of the cell’s most important signal-transducing molecules, responding to a diversity of extracellular cues to regulate a number of central processes, including proliferation, metabolism, migration and death [1]. It is also one of the more complex signal transducers, constituting a family of serine/threonine kinases that can phosphorylate a multitude of cellular sub...
متن کاملIL-1R-associated kinase-1 mediates protein kinase Cδ-induced IL-1β production in monocytes.
The role of IL-1R-associated kinase (IRAK)1 and its interaction with protein kinase C (PKC)δ in monocytes to regulate IL-1β production has not been reported so far. The present study thus investigates such mechanisms in the THP1 cell line and human monocytes. PMA treatment to THP1 cells induced CD11b, TLR2, TLR4, CD36, IRAK1, IRAK3, and IRAK4 expression, IRAK1 kinase activity, PKCδ and JNK phos...
متن کاملProtein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage–induced apoptosis
Vaccinia-related kinase 1 (VRK1) is a novel serine/threonine kinase that plays an important role in cell proliferation. However, little is known about the upstream regulators of VRK1 activity. Here we provide evidence for a role of protein kinase Cδ (PKCδ) in the regulation of murine VRK1. We show that PKCδ interacts with VRK1, phosphorylates the Ser-355 residue in the putative regulatory regio...
متن کاملProtein kinase Cδ promotes proliferation and induces malignant transformation in skeletal muscle
In this paper, we investigated the isoform-specific roles of certain protein kinase C (PKC) isoforms in the regulation of skeletal muscle growth. Here, we provide the first intriguing functional evidence that nPKCδ (originally described as an inhibitor of proliferation in various cells types) is a key player in promoting both in vitro and in vivo skeletal muscle growth. Recombinant overexpressi...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2001
ISSN: 0014-2956
DOI: 10.1046/j.1432-1327.1999.00120.x